Project details - Risk assessment of food chemicals research programme T01
Information about Agency-funded research projects
T01003/4/5: Research on red meat consumption and large bowel cancer
These interlinked research projects aimed to establish the role of heterocyclic amines in colorectal cancer and to determine whether particular genetic groups of the population are at a greater risk.
Results available.
T01007: Food risk assessment (FORA) fellowship
This research project was a multidisciplinary collaboration combining development of biomarkers of DNA damage, biomarker use in human studies and research workshops.
Results available.
T01008:Development of an in vitro intestinal cell model to predict bioavailability of food components in humans
This research project aimed to establish an in vitro intestinal cell model for prediction of in vivo bioavailability of food components from the human diet.
Results available.
T01009: Can cruciferous vegetables alter the genotoxicity of heterocyclic amines following human consumption of cooked meat?
This research project investigates the effects of cruciferous vegetables upon the metabolism of potentially harmful genotoxins present in cooked meat.
Results available.
T01010: Cruciferous vegetables and drug metabolising enzyme phenotype
This research project investigates which drug-metabolising enzymes are present in human colon and whether expression is affected by cruciferous vegetable extracts.
Results available.
T01011: New developments of cultured precision-cut tissue slices for studies of organ pharmaco-toxicology
This research project aims to develop in vitro methodology for investigating the toxicological effects of dietary chemicals in liver and lung tissue.
Results available.
T01012: The interactions of genotoxins ' a mechanistic approach based on DNA repair
This research project examines the effects of heterocyclic amines and oxidative agents on the level of DNA adduct formation and repair in liver cells
Results available.
T01013: Development of probabilistic models for describing individual intakes of chemical residues in food
This research project describes the development and use of probabilistic models to look at patterns of food consumption and intakes of food chemicals.
Results available.
T01014: Modelling of between - and within - individual variation in intakes of chemicals in food
This research project aims to produce a statistical model which can estimate variability in dietary intake, between-person and within-person, whilst accounting for day-to-day variation.
Results available.
T01015/T01019: Development of biomarkers based on cell cycling and proliferation to facilitate the risk assessment of food chemicals
This research project seeks to develop biomarkers that are predictive of subsequent tumour formation by non-genotoxic chemicals.
T01016: Comparison of DNA damage and repair in target versus non-target cells - relevance to diet and colon cancer
This research project aims to assess the DNA adducts, and the repair activities which modulate these levels, in the target cells.
T01017: Biomarkers, toxicokinetics and default safety factors
This research project aims to assess whether current default safety factors which are used in the risk assessment of food additives are sufficient to protect the consumer.
T01018: Stem cell mutation indices as biomarkers of dietary chemical effect - use in short term assays of carcinogenic potential of food components
This research project seeks to develop a new model to address interactions between genotoxic and non-genotoxic food components of diets.
T01021: Development of methods for the assessment of the health effects from mixtures of food additives
This research project aims to develop methods to assess the health effects from mixtures of food chemicals using four well characterised food additives.
T01022: The influence of diet and genetic polymorphisms on susceptibility to colorectal adenomas
This project investigates the influence of diet and genetic factors on susceptibility to colorectal adenomas and factors that predispose certain adenomas to become colorectal cancers.
T01024: Investigation into the genotoxicity of 1,3-dichloropropan-2-ol (1,3-DCP) and 2,3-dichloropropan-1-ol (2,3-DCP) in vivo
This research project sought to determine whether 1,3-DCP and 2,3-DCP were genotoxic when tested using standard in vivo genotoxicity tests.
Results available.
T01025: Molecular biomarkers of toxicity from dietary chemicals
This research project seeks to establish a strategy to identify molecular biomarkers of toxicity to assess early changes following exposure to potential neurotoxicants.
T01026: Potential toxicity of vitamin C supplements - an in vitro and in vivo comparison assessed by genotoxicity and gene-expression profiling
This research project aims to evaluate the potential toxicity of vitamin C supplements in a large number of human volunteers at high doses.
T01027: Influence of cooking and processing of Brassica vegetables on release of beneficial and harmful metabolites of glucosinolates in the digestive tract
This research project aims to develop urinary markers for estimation of in vivo production of glucosinolate hydrolysis products.
Results available.
T01028: Glucosinolate stability in culinary processing and storage
This research project seeks to study the effects of vegetable storage, preparation and cooking, on glucosinolate and related metabolite content of Brassica vegetables.
Results available.
T01029: Evaluation of the existence of thresholds of genotoxic activity with respect to substances identified in food
This project investigated, using the in vitro binucleate micronucleus assay, whether the concept of non-linear, threshold dose-response relationships can be applied to at least a proportion of the potentially mutagenic chemicals found in food.
T01030: Biological relevance of apparent total nitroso compounds in the human colon
This research project aims to investigate the relevance of elevated apparent total nitrosocompounds in the human colon, resulting from increased red meat consumption.
T01031: The relevance of ATNC to colon carcinogenesis measurement of nitroso compounds by MS or LC-MS or LC-MS-MS
This research project proposes to determine the chemical nature of faecal ATNC together with its route of formation.
Results available.
T01032: Determination of maternal caffeine intakes associated with increased risk to the foetus
This research project will address the issue of whether high maternal caffeine intake during pregnancy leads to an increased incidence of low birth weight babies.
T01033: Assessment of caffeine consumption, altered caffeine metabolism and pregnancy outcome
This research project will address the issue of whether high maternal caffeine intake during pregnancy leads to an increased incidence of low birth weight babies.
T01034: Risk assessment of dietary dioxins
This research project aims to refine the risk assessment of the human health effects of dioxins and dioxin-like PCBs ingested through the diet.
T01035: Signal transduction pathways involved in cell proliferation and motility induced by the food-derived carcinogen PhIP
This research project investigates whether PhIP, or its metabolites, influence cell proliferation and cell growth.
Results available.
T01037: Collection and analysis of honey samples potentially contaminated with pyrrolizidine alkaloids from ragwort and borage, assessment of the stability of these compounds during storage of honey
This research project aims to assess the levels of pyrrolizidine alkaloids in honey produced by bees living in hives close to areas where ragwort or borage are growing.
Results available.
T01038: The evaluation of the genotoxicity and concentration-response relationships of the azo dyes Sudan 1 and Para Red
This research project seeks to evaluate the genotoxicity of azo dyes and to investigate whether the genotoxicity occurs via a threshold mechanism
T01040 – Development of methods for the assessment of the health effects from mixtures of food additives
This research project aims to develop methods to assess the health effects from mixtures of food chemicals by using four well characterised food additives.
T01041 – Development of methods for the assessment of the health effects from mixtures of food additives
This research project aims to develop methods to assess the health effects from mixtures of food chemicals using four well characterised food additives.
T01042: Quality of life-integrated benefit and risk analysis: Web-based tool for assessing food safety and health benefits (QALIBRA)
This research project aims to develop a suite of quantitative methods for assessing and integrating beneficial and adverse effects of foods as web-based software.
T01045: The assessment of joint endocrine effects of multi-component mixtures of food contaminants and additives
This research project will investigate the effects of mixtures of food contaminants and additives with different modes of action.
T01048 Effect of cruciferous vegetable dietary intervention in humans on urinary metabonomic profile
This short research project aims to add to existing information on the reported anticancer effects of eating cruciferous vegetables using samples collected as part for a previous FSA project.