T07 Project details
Details of Agency-funded projects under the Food Allergy research programme (T07).
T07001: The prevalence and natural history of peanut allergy and the investigation into its genetic environment and immunological determinants
This research project aims to investigate the prevalence of peanut allergy in UK children and the factors affecting the development of peanut allergy.
Results available.
T07002: Development of food intolerance in atopic and non-atopic families - influence of maternal nutrition and infant feeding practice in pre-term infants
This research projects aim to look at how such factors as feeding practices, a child's sex and social conditions influence the development of food intolerances in babies that were born prematurely.
Results available.
T07003: Investigation of the immunological mechanism inducing cows’ milk sensitive enteropathy
This research project aims to investigate a possible link between the biological basis for allergy to cows' milk and the general rise in allergies among children.
Results available.
T07004: Do food additives cause hyperactivity and behaviour problems in a geographically defined population of 3-5 year olds?
This research project aims to find out whether certain food additives influence the behaviour of young children.
Results available.
T07005: The effect of exposure to food protein via maternal sources on the development of food allergy in infants with a family history of atopy
This research project investigates whether eating eggs during pregnancy and breastfeeding has any influence on the incidence of egg allergy in infants.
Results available.
T07006: Adverse reactions to foods
This research project aims to identify and describe components in certain foods that cause a condition known as oral allergy syndrome.
Results available.
T07007: A clinical trial to investigate potential allergic reactions from the ingestion of storage mites
This research project aims to assess the level of non-occupational allergy to four common storage mites in a large population with a family history of allergy.
Results available.
T07008: Development of methods to predict the allergenic potential of genetically modified foods
This research project aims to develop a method to predict if genetically modified foods, and new protein products, could cause food allergy.
Results available.
T07009: Development of an in-vitro screening method for allergens in novel foods
This research project aims to develop a method for testing for allergens in new foods.
Results available.
T07010: Allergic cross-reactivity in peanut allergy
This research looks at the relationship between the development of allergy to peanuts and other foods that cause allergy.
Results available.
T07011: Immunochemical reactivity to peanuts and nuts in allergic individuals
This research project aims to examine the basis for the apparent difference in allergic reaction to peanuts and nuts between young children and adults.
Results available.
T07012, T07013 and T07014: Investigation of cross-reactivities towards peanut and other nuts in relation to the age of the allergic individuals
These research projects aim to find out whether age is related to the development of allergy to more than one type of nut.
Results available.
T07015: Peanut allergens associated with provoking clinical symptoms
This research project will examine whether all allergenic proteins found in peanut have a potent symptom-provoking ability or if this is limited to some proteins.
Results available.
T07016: Investigation of immune responses to food allergens in individuals with a clinical spectrum of sensitivity to different foods
This research project aims to look at people with multiple allergies and examine why some foods cause serious symptoms in some people, while others will cause only mild or no symptoms at all.
Results available.
T07018: Allergen specific antibody binding characteristics and longitudinal serological changes to purified allergens
This project aims to examine the role that affinity/avidity (strength/quality) of antibody binding to major peanut allergens has in the persistence of peanut allergy.
Results available.
T07019: Do protein structural features confer stability to digestion of food allergens?
This research project aims to determine whether structural features of proteins affect their allergenicity.
Results available.
T07022: Can topical exposure to peanuts induce allergic sensitisation or in combination with mucosal exposure?
This research project aims to determine whether allergic sensitisation to peanut protein or chicken egg ovalbumin (OVA) can occur via exposure of the skin.
Results available.
T07023: Prevalence and incidence of food allergies and food intolerance
This research project aims to establish how common food allergy is among a group of children between birth and 15 years of age.
Results available.
T07024: The development of PCR based method for the identification of peanut in commercial products
This research project aims to develop a laboratory method to detect peanuts in food products.
Results available.
T07025: Factors influencing the susceptibility to, and characteristics of kiwi fruit allergy
This research project aims to describe the clinical characteristics of allergy to kiwi in adults and children.
Results available.
T07026: To investigate the influence of the maternal experience of dietary antigen on the subsequent immune status of their offspring
This research aims to find out if piglets born to mothers that are immunologically sensitive to certain allergens are also sensitive to the same allergens.
Results available.
T07027: The interaction of food allergens with the epithelium of the alimentary canal: investigation of non-immunological determinants of allergenicity
This research project examines the hypothesis that certain foods are more likely to cause allergic reactions because of their proteolytic (enzyme) activity.
Results available.
T07028: The influence of dose and route of exposure on the early life origins of peanut allergy
This project aims to establish whether avoiding peanuts during pregnancy and breastfeeding has any effect on the development of peanut allergy in a woman's children.
Results available.
T07032: The role of IgG in allergy and tolerance to common food allergens
This project aims to establish the role of IgG in the development of allergic sensitisation and reactions to foods.
Results available.
T07033: The immunomodulatory role of maternal IgG in infant atopic programming
This project aims to investigate if differences in maternal IgG during pregnancy direct the form of allergen encountered in utero and later infant atopic phenotype.
T07034: An investigation into trends of peanut allergy incidence in the last 15 years in England using sequential childhood cohorts
This project aims to establish whether the issuing of the Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) advice has resulted in a change in the incidence of peanut allergy.
T07035: The prevalence of peanut allergy in British children at school entry age in 2003
This project is evaluating the impact of the Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) report, that recommends atopic mothers avoid peanuts during pregnancy and breastfeeding, on the prevalence of peanut allergy.
T07036: Development, recognition and significance of IgG antibodies in allergic sensitisation and adverse reactions
This research assesses links between levels of peanut-specific IgG, using archive samples from patients with varying reactions to peanut.
Results available.
T07037: Fatal asthma and food allergy
This research aims to determine the incidence and the trigger factors of fatal acute asthma in subjects up to the age of 32.
Results available.
T07038: The characteristics of kiwi fruit allergy
This project aims to fully characterise all of the clinical symptoms associated with allergy to kiwi fruit.
T07039: Determination of the role of an activating c-kit mutation in food anaphylaxis
This project aims to investigate if there is a possible link between an activating mutation in the c-kit oncogene and the risk of developing severe food allergy.
Results available.
T07040: Chronic and acute effects of artificial colourings and preservatives on children's behaviour
This research project examines the impact of artificial food colourings and preservatives on children's behaviour.
Results available.
T07041: The role of peanut-specific T cell responses in children with peanut allergy and in children who are tolerant to peanuts
This research project will further our understanding of T cell responses in tolerant individuals thereby devising immunomodulatory strategies to normalise T cell responses in future therapies.
T07042: Study of T cells in allergy and resolution
This research project aims to understand the role of T cells in regulating responses to allergen and in the pathogenesis of allergy and resolution.
T07043: Peanut allergy - routes of pre-natal and post-natal exposure
This research project is a retrospective case controlled study investigating the role of infant's environmental peanut exposure on later allergy.
Results available.
T07044: Peri-natal egg and milk allergen exposure in relation to tolerance or allergic sensitisation to food in infancy
This research project will investigate maternal exposure to dietary egg and milk during pregnancy and lactation and its role in the immune outcome of infants.
T07045: Food allergy and intolerance research
This project will explore the information needs of teenagers and young adults in relation to food allergy/intolerance and determine how best to meet them.
Results available.
T07046: The prevalence of food allergy and weaning practices in a birth cohort of UK infants
This project will investigate the prevalence of food allergies and the current infant weaning practices adopted by mothers in the UK
ZT0702: Allergen database service
This research project aims to improve clinical management of food allergy by analysing detailed clinical and laboratory data from patients attending a local allergy clinic with suspected nut allergy.